| 1. Round | 09/07/2016 | Libertad | - | River Plate | 1:1 |  |
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| 2. Round | 16/07/2016 | River Plate | - | General Díaz | 0:0 | ||||
| 3. Round | 20/07/2016 | Guaraní | - | River Plate | 2:0 | |
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| 4. Round | 24/07/2016 | River Plate | - | Club Olimpia | 0:2 | ||||
| 5. Round | 01/08/2016 | Club Rubio Ñu | - | River Plate | 5:1 | ||||
| 10. Round | 10/09/2016 | Sol de América | - | River Plate | 2:6 | |
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| 11. Round | 18/09/2016 | River Plate | - | Club Nacional | 2:3 | ||||
| 12. Round | 24/09/2016 | River Plate | - | Libertad | 2:0 | ||||
| 17. Round | 05/11/2016 | General Caballero ZC | - | River Plate | 1:0 | ||||
| 18. Round | 18/11/2016 | River Plate | - | Sportivo Luqueño | 0:2 | ||||
| 19. Round | 26/11/2016 | River Plate | - | Deportivo Capiatá | 2:4 | |
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| 20. Round | 02/12/2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 21. Round | 10/12/2016 | River Plate | - | Sol de América | 2:4 | ||||
| 22. Round | 17/12/2016 | Club Nacional | - | River Plate | 2:0 | |
Paraguay