| 6. Round | 17/10/2021 | AEK Athen | - | Atromitos | 3:0 | ||||
| 7. Round | 24/10/2021 | Volos NFC | - | AEK Athen | 1:3 | ||||
| 8. Round | 31/10/2021 | AEK Athen | - | Aris Saloniki | 2:1 |  |
 |
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| 10. Round | 21/11/2021 | AEK Athen | - | Olympiakos Piraeus | 2:3 | ||||
| 11. Round | 27/11/2021 | PAS Giannina | - | AEK Athen | 1:2 | ||||
| 12. Round | 05/12/2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 14. Round | 16/12/2021 | Ionikos Nikea | - | AEK Athen | 0:1 | ||||
| 16. Round | 05/01/2022 | Lamia | - | AEK Athen | 0:2 | ||||
| 19. Round | 23/01/2022 | Atromitos | - | AEK Athen | 0:2 | ||||
| 20. Round | 30/01/2022 | AEK Athen | - | Volos NFC | 1:2 | ||||
| 21. Round | 02/02/2022 | Aris Saloniki | - | AEK Athen | 2:1 | ||||
| 22. Round | 06/02/2022 | AEK Athen | - | Apollon Smyrnis | 3:0 | ||||
| 23. Round | 13/02/2022 | Olympiakos Piraeus | - | AEK Athen | 1:0 | ||||
| 26. Round | 06/03/2022 | AEK Athen | - | Asteras Tripolis | 2:1 |
Greece