| 1. Round | 31/07/2022 | Danubio | - | Cerrito | 0:0 | ||||
| 2. Round | 07/08/2022 | Danubio | - | Deportivo Maldonado | 0:0 | ||||
| 3. Round | 13/08/2022 | Rentistas | - | Danubio | 0:1 | ||||
| 6. Round | 19/08/2022 | Danubio | - | Montevideo City Torque | 3:2 | ||||
| 5. Round | 28/08/2022 | Peñarol | - | Danubio | 1:1 |  |
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| 4. Round | 03/09/2022 | Danubio | - | Liverpool | 1:1 | |
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| 7. Round | 10/09/2022 | Montevideo Wanderers | - | Danubio | 0:3 | ||||
| 8. Round | 13/09/2022 | Danubio | - | Plaza Colonia | 1:1 | ||||
| 9. Round | 19/09/2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Round | 24/09/2022 | Danubio | - | River Plate | 3:0 | ||||
| 11. Round | 30/09/2022 | Cerro Largo | - | Danubio | 1:0 | ||||
| 12. Round | 08/10/2022 | Danubio | - | Fénix | 1:1 | ||||
| 13. Round | 13/10/2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Round | 16/10/2022 | Danubio | - | Albion | 3:0 | ||||
| 15. Round | 23/10/2022 | Nacional | - | Danubio | 2:0 |
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