| 1. Round | 18/08/2021 | Progrès Niedercorn | - | FC Differdange 03 | 3:0 | ||||
| 3. Round | 22/08/2021 | FC Differdange 03 | - | CS FOLA Esch | 1:1 | ||||
| 5. Round | 12/09/2021 | FC Differdange 03 | - | Swift Hesperange | 0:0 |  |
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| 7. Round | 22/09/2021 | FC Differdange 03 | - | RM Hamm Benfica | 3:0 | ||||
| 9. Round | 17/10/2021 | FC Differdange 03 | - | F91 Dudelange | 3:2 | ||||
| 11. Round | 07/11/2021 | FC Differdange 03 | - | US Hostert | 1:4 | |
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| 13. Round | 28/11/2021 | FC Differdange 03 | - | Union Titus Pétange | 4:0 | ||||
| 14. Round | 05/12/2021 | US Mondorf | - | FC Differdange 03 | 3:3 | |
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| 16. Round | 06/02/2022 | FC Differdange 03 | - | Victoria Rosport | 4:0 | ||||
| 26. Round | 24/04/2022 | FC Differdange 03 | - | RFCU Luxemburg | 4:0 | ||||
| 28. Round | 08/05/2022 | FC Differdange 03 | - | US Mondorf | 1:0 | ||||
| 29. Round | 15/05/2022 | Etzella Ettelbruck | - | FC Differdange 03 | 0:2 | ||||
| 30. Round | 22/05/2022 | FC Differdange 03 | - | Progrès Niedercorn | 2:0 |
Luxembourg
Italy