| 2. Round | 19/09/2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 |  |
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| 3. Round | 22/09/2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
| 4. Round | 26/09/2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
| 5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
| 6. Round | 17/10/2021 | PAOK Saloniki | - | Volos NFC | 4:4 | |
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| 7. Round | 24/10/2021 | Olympiakos Piraeus | - | PAOK Saloniki | 2:1 | ||||
| 8. Round | 30/10/2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 |  |
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| 9. Round | 07/11/2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | |
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| 11. Round | 28/11/2021 | PAOK Saloniki | - | Aris Saloniki | 0:1 | ||||
| 12. Round | 05/12/2021 | Ionikos Nikea | - | PAOK Saloniki | 3:2 | ||||
| 13. Round | 12/12/2021 | PAOK Saloniki | - | Lamia | 2:1 | |
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| 16. Round | 12/01/2022 | PAOK Saloniki | - | Panetolikos | 2:0 | ||||
| 19. Round | 23/01/2022 | Volos NFC | - | PAOK Saloniki | 0:4 | ||||
| 21. Round | 02/02/2022 | Apollon Smyrnis | - | PAOK Saloniki | 0:2 | ||||
| 22. Round | 06/02/2022 | PAOK Saloniki | - | Panathinaikos | 2:1 | ||||
| 24. Round | 20/02/2022 | Aris Saloniki | - | PAOK Saloniki | 0:0 | ||||
| 25. Round | 27/02/2022 | PAOK Saloniki | - | Ionikos Nikea | 1:1 | |
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| 26. Round | 06/03/2022 | Lamia | - | PAOK Saloniki | 0:2 | |
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Greece