| 1. Round | 07/11/2021 | AEP Iraklis FC | - | Niki Volou FC | 0:0 | ||||
| 3. Round | 20/11/2021 | AEP Iraklis FC | - | PAOK Saloniki II | 0:0 | ||||
| 19. Round | 16/02/2022 | AEP Iraklis FC | - | Olympiakos Volou | 4:0 | ||||
| 20. Round | 20/02/2022 | PAOK Saloniki II | - | AEP Iraklis FC | 0:0 | ||||
| 22. Round | 06/03/2022 | AE Lárissa | - | AEP Iraklis FC | 3:0 | ||||
| 30. Round | 10/04/2022 | AEP Iraklis FC | - | Pierikos Katerini | 4:2 | ||||
| 31. Round | 13/04/2022 | Xanthi FC | - | AEP Iraklis FC | 3:3 | ||||
| 32. Round | 17/04/2022 | AEP Iraklis FC | - | Thesprotos | 6:0 |
Greece