| 3. Round | 17/09/2024 | FC Twente | - | sc Heerenveen | 2:0 | ||||
| 7. Round | 29/09/2024 | FC Twente | - | NAC Breda | 1:0 |  |
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| 8. Round | 06/10/2024 | Feyenoord | - | FC Twente | 2:1 | ||||
| 11. Round | 02/11/2024 | Willem II | - | FC Twente | 0:1 | ||||
| 12. Round | 10/11/2024 | FC Twente | - | AFC Ajax | 2:2 | |
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| 13. Round | 23/11/2024 | Fortuna Sittard | - | FC Twente | 1:2 | ||||
| 17. Round | 21/12/2024 | AZ Alkmaar | - | FC Twente | 1:0 | ||||
| 21. Round | 02/02/2025 | Go Ahead Eagles | - | FC Twente | 2:2 | ||||
| 20. Round | 23/02/2025 | FC Twente | - | NEC Nijmegen | 2:0 | ||||
| 25. Round | 09/03/2025 | FC Twente | - | Almere City FC | 1:0 | ||||
| 26. Round | 16/03/2025 | FC Twente | - | Feyenoord | 2:6 | ||||
| 29. Round | 13/04/2025 | PEC Zwolle | - | FC Twente | 1:1 |
Netherlands