| 1. Round | 18/08/2021 | FSV Gütersloh 2009 [Women] | - | MSV Duisburg [Women] | 1:2 | ||||
| 4. Round | 12/09/2021 | MSV Duisburg [Women] | - | Bayern München II [Women] | 2:1 | ||||
| 5. Round | 03/10/2021 | Eintracht Frankfurt II [Women] | - | MSV Duisburg [Women] | 1:3 | ||||
| 8. Round | 07/11/2021 | MSV Duisburg [Women] | - | Borussia Bocholt [Women] | 3:0 | ||||
| 9. Round | 14/11/2021 | SV 07 Elversberg [Women] | - | MSV Duisburg [Women] | 1:5 | ||||
| 13. Round | 19/12/2021 | RB Leipzig [Women] | - | MSV Duisburg [Women] | 3:0 | ||||
| 10. Round | 13/02/2022 | MSV Duisburg [Women] | - | FC Ingolstadt 04 [Women] | 3:2 |  |
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| 19. Round | 03/04/2022 | SV Meppen [Women] | - | MSV Duisburg [Women] | 2:0 | ||||
| 20. Round | 17/04/2022 | MSV Duisburg [Women] | - | SG 99 Andernach [Women] | 3:0 | ||||
| 21. Round | 24/04/2022 | Borussia Bocholt [Women] | - | MSV Duisburg [Women] | 0:2 | ||||
| 22. Round | 01/05/2022 | MSV Duisburg [Women] | - | SV 07 Elversberg [Women] | 6:1 | ||||
| 23. Round | 08/05/2022 | FC Ingolstadt 04 [Women] | - | MSV Duisburg [Women] | 1:2 |
Germany