| 1. Round | 04/04/2021 | CD Magallanes | - | San Marcos | 1:3 | ||||
| 2. Round | 19/04/2021 | Santiago Morning | - | CD Magallanes | 1:2 | ||||
| 3. Round | 26/04/2021 | Coquimbo Unido | - | CD Magallanes | 1:1 | ||||
| 8. Round | 30/05/2021 | Barnechea | - | CD Magallanes | 0:1 | ||||
| 9. Round | 07/06/2021 | CD Magallanes | - | Cobreloa | 2:2 |  |
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| 13. Round | 02/08/2021 | CD Magallanes | - | Deportes Copiapó | 3:0 | ||||
| 15. Round | 16/08/2021 | CD Magallanes | - | Unión San Felipe | 2:1 | ||||
| 16. Round | 22/08/2021 | San Marcos | - | CD Magallanes | 1:2 |  |
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| 17. Round | 27/08/2021 | CD Magallanes | - | Santiago Morning | 0:1 | ||||
| 19. Round | 06/09/2021 | Deportes Temuco | - | CD Magallanes | 3:0 | |
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| 20. Round | 16/09/2021 | CD Magallanes | - | Puerto Montt | 3:0 | ||||
| 22. Round | 27/09/2021 | CD Magallanes | - | Deportes Iquique | 2:2 | |
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| 23. Round | 02/10/2021 | CD Magallanes | - | Barnechea | 1:1 | ||||
| 25. Round | 13/10/2021 | CD Magallanes | - | Universidad de Concepción | 3:0 | ||||
| 26. Round | 16/10/2021 | Fernández Vial | - | CD Magallanes | 0:1 | ||||
| 28. Round | 30/10/2021 | Deportes Copiapó | - | CD Magallanes | 1:1 | ||||
| 29. Round | 06/11/2021 | CD Magallanes | - | San Luis | 3:3 | ||||
| 30. Round | 13/11/2021 | Unión San Felipe | - | CD Magallanes | 0:0 |
Chile