| 22. Round | 08/08/2021 | Dinamo Batumi | - | FC Samtredia | 3:1 | ||||
| 23. Round | 13/08/2021 | FC Samtredia | - | Lokomotiv Tbilisi | 1:0 | ||||
| 24. Round | 16/09/2021 | Samgurali Tskhaltubo | - | FC Samtredia | 4:0 | ||||
| 25. Round | 20/09/2021 | FC Samtredia | - | Torpedo Kutaisi | 4:1 | ||||
| 26. Round | 24/09/2021 | Dinamo Tbilisi | - | FC Samtredia | 5:1 |  |
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| 27. Round | 29/09/2021 | FC Samtredia | - | FC Saburtalo | 0:2 | ||||
| 28. Round | 03/10/2021 | FC Samtredia | - | FC Telavi | 0:2 | ||||
| 29. Round | 16/10/2021 | Dila Gori | - | FC Samtredia | 3:1 | |
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| 30. Round | 20/10/2021 | FC Samtredia | - | Shukura Kobuleti | 1:1 | ||||
| 31. Round | 24/10/2021 | FC Samtredia | - | Dinamo Batumi | 1:0 | ||||
| 32. Round | 01/11/2021 | Lokomotiv Tbilisi | - | FC Samtredia | 4:2 | ||||
| 33. Round | 07/11/2021 | FC Samtredia | - | Samgurali Tskhaltubo | 1:2 | ||||
| 34. Round | 21/11/2021 | Torpedo Kutaisi | - | FC Samtredia | 4:1 | ||||
| 35. Round | 28/11/2021 | FC Samtredia | - | Dinamo Tbilisi | 0:0 | ||||
| 36. Round | 04/12/2021 | FC Saburtalo | - | FC Samtredia | 5:1 | |
Georgia