| 12. Round | 02/01/2001 | Iraklis Saloniki | - | Olympiakos Piraeus | 2:1 | ||||
| 13. Round | 06/01/2001 | Athinaikos | - | Iraklis Saloniki | 2:0 |  |
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| 14. Round | 13/01/2001 | Iraklis Saloniki | - | Ethnikos Asteras | 4:0 | ||||
| 15. Round | 20/01/2001 | Ionikos Nikea | - | Iraklis Saloniki | 2:2 |  |
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| 16. Round | 27/01/2001 | Iraklis Saloniki | - | AEK Athen | 1:2 | ||||
| 17. Round | 03/02/2001 | Panachaiki GE | - | Iraklis Saloniki | 1:2 |  |
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| 19. Round | 17/02/2001 | PAS Giannina | - | Iraklis Saloniki | 3:2 | ||||
| 20. Round | 24/02/2001 | Iraklis Saloniki | - | Panionios GSS | 4:3 | ||||
| 21. Round | 02/03/2001 | Iraklis Saloniki | - | Aris Saloniki | 1:2 | |
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| 23. Round | 17/03/2001 | Iraklis Saloniki | - | Paniliakos Pyrgos | 1:0 | |
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| 24. Round | 31/03/2001 | Panathinaikos | - | Iraklis Saloniki | 2:1 | ||||
| 25. Round | 07/04/2001 | Iraklis Saloniki | - | PAOK Saloniki | 1:1 | |
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| 26. Round | 19/04/2001 | Skoda Xanthi | - | Iraklis Saloniki | 1:0 | |
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| 29. Round | 19/05/2001 | Ethnikos Asteras | - | Iraklis Saloniki | 2:0 |
Greece