| 1. Round | 27/03/2022 | Deportivo Cuenca [Women] | - | Leones del Norte [Women] | 0:3 | ||||
| 2. Round | 03/04/2022 | Deportivo Cuenca [Women] | - | Emelec [Women] | 3:5 | ||||
| 3. Round | 15/04/2022 | Espuce FC [Women] | - | Deportivo Cuenca [Women] | 2:0 |  |
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| 4. Round | 24/04/2022 | Deportivo Cuenca [Women] | - | Dragonas IDV [Women] | 1:5 | ||||
| 5. Round | 30/04/2022 | Macará [Women] | - | Deportivo Cuenca [Women] | 1:0 | ||||
| 7. Round | 14/05/2022 | Quito FC [Women] | - | Deportivo Cuenca [Women] | 3:2 |  |
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| 8. Round | 20/05/2022 | Leones del Norte [Women] | - | Deportivo Cuenca [Women] | 3:0 | ||||
| 9. Round | 28/05/2022 | Emelec [Women] | - | Deportivo Cuenca [Women] | 3:1 | ||||
| 10. Round | 04/06/2022 | Deportivo Cuenca [Women] | - | Espuce FC [Women] | 1:3 | ||||
| 11. Round | 11/06/2022 | Dragonas IDV [Women] | - | Deportivo Cuenca [Women] | 8:0 | ||||
| 12. Round | 22/07/2022 | Deportivo Cuenca [Women] | - | Macará [Women] | 0:1 | ||||
| 13. Round | 30/07/2022 | Ñañas [Women] | - | Deportivo Cuenca [Women] | 2:2 | |
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| 14. Round | 06/08/2022 | Deportivo Cuenca [Women] | - | Quito FC [Women] | 1:4 |
Ecuador