| 5. Round | 21/08/2021 | SShOR Zenit [Youth] | - | FK Strogino Moskva [Youth] | 2:1 |  |
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| 6. Round | 25/08/2021 | SShOR Zenit [Youth] | - | Chertanovo Football Academy [Youth] | 1:1 | ||||
| 7. Round | 11/09/2021 | SShOR Zenit [Youth] | - | FK Rostov [Youth] | 0:2 | ||||
| 8. Round | 18/09/2021 | Kuban Krasnodar [Youth] | - | SShOR Zenit [Youth] | 0:2 | ||||
| 9. Round | 25/09/2021 | SShOR Zenit [Youth] | - | Rubin Kazan [Youth] | 6:3 | |
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| 10. Round | 02/10/2021 | FShM Moskva [Youth] | - | SShOR Zenit [Youth] | 1:1 | ||||
| 11. Round | 16/10/2021 | SShOR Zenit [Youth] | - | Zenit St. Petersburg [Youth] | 1:1 | ||||
| 12. Round | 23/10/2021 | SShOR Zenit [Youth] | - | FK Saturn [Youth] | 0:2 | ||||
| 15. Round | 20/11/2021 | Dinamo Moskva [Youth] | - | SShOR Zenit [Youth] | 1:2 | ||||
| 16. Round | 27/11/2021 | CSKA Moskva [Youth] | - | SShOR Zenit [Youth] | 3:1 |  |
Russia