| 1. Round | 15/05/2021 | Villa Española | - | Progreso | 0:0 |  |
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| 2. Round | 23/05/2021 | Progreso | - | Nacional | 1:3 | ||||
| 3. Round | 29/05/2021 | Cerrito | - | Progreso | 0:0 | ||||
| 4. Round | 04/06/2021 | Progreso | - | Liverpool | 1:3 | ||||
| 5. Round | 12/06/2021 | River Plate | - | Progreso | 4:0 | ||||
| 6. Round | 19/06/2021 | Progreso | - | Cerro Largo | 0:0 | |
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| 7. Round | 24/06/2021 | Deportivo Maldonado | - | Progreso | 1:1 | ||||
| 8. Round | 29/06/2021 | Sud América | - | Progreso | 2:4 | |
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| 9. Round | 05/07/2021 | Progreso | - | Plaza Colonia | 1:2 | ||||
| 10. Round | 11/07/2021 | Fénix | - | Progreso | 2:1 | ||||
| 11. Round | 16/07/2021 | Progreso | - | Boston River | 1:0 | ||||
| 12. Round | 31/07/2021 | Montevideo Wanderers | - | Progreso | 2:0 | ||||
| 14. Round | 14/08/2021 | Peñarol | - | Progreso | 1:0 |
Uruguay