| 1. Round | 17/02/2019 | Cerro Largo | - | Danubio | 2:0 |  |
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| 3. Round | 03/03/2019 | Danubio | - | CA Cerro | 1:0 | ||||
| 4. Round | 10/03/2019 | River Plate | - | Danubio | 1:1 |  |
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| 5. Round | 16/03/2019 | Danubio | - | Nacional | 2:0 | ||||
| 6. Round | 23/03/2019 | Fénix | - | Danubio | 5:1 | |
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| 7. Round | 31/03/2019 | Danubio | - | Progreso | 3:2 | ||||
| 8. Round | 06/04/2019 | Peñarol | - | Danubio | 1:0 | |
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| 9. Round | 13/04/2019 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 10. Round | 20/04/2019 | Rampla Juniors | - | Danubio | 0:0 | |
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| 12. Round | 11/05/2019 | Liverpool | - | Danubio | 0:5 |  |
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| 13. Round | 18/05/2019 | Danubio | - | Montevideo Wanderers | 0:2 | |
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| 15. Round | 02/06/2019 | Danubio | - | Boston River | 1:0 |
Uruguay
Italy