| 5. Round | 08/08/2021 | Colorado Rapids | - | Sporting Kansas City | 0:0 | ||||
| 5. Round | 15/08/2021 | FC Dallas | - | Sporting Kansas City | 0:2 | ||||
| 5. Round | 21/08/2021 | Minnesota United FC | - | Sporting Kansas City | 0:0 | ||||
| 6. Round | 16/09/2021 | Sporting Kansas City | - | Minnesota United FC | 4:0 | ||||
| 6. Round | 30/09/2021 | FC Dallas | - | Sporting Kansas City | 1:3 |  |
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| 7. Round | 28/10/2021 | Sporting Kansas City | - | Los Angeles Galaxy | 2:0 | ||||
| 7. Round | 31/10/2021 | Minnesota United FC | - | Sporting Kansas City | 2:1 | ||||
| 8. Round | 04/11/2021 | Austin FC | - | Sporting Kansas City | 3:1 | ||||
| 8. Round | 07/11/2021 | Sporting Kansas City | - | Real Salt Lake | 0:1 |
USA