| 2. Round | 01/08/2010 | Oriente Petrolero | - | Real Potosí | 3:1 | ||||
| 4. Round | 14/08/2010 | Bolívar | - | Real Potosí | 2:0 | ||||
| 5. Round | 21/08/2010 | Real Potosí | - | Real Mamoré | 4:0 | ||||
| 3. Round | 26/08/2010 | Real Potosí | - | Club Aurora | 2:1 |  |
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| 6. Round | 28/08/2010 | Club San José | - | Real Potosí | 2:3 | |
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| 7. Round | 05/09/2010 | Real Potosí | - | Universitario de Sucre | 1:1 | ||||
| 8. Round | 09/09/2010 | Blooming | - | Real Potosí | 2:2 | ||||
| 9. Round | 12/09/2010 | Real Potosí | - | Jorge Wilstermann | 2:1 | ||||
| 10. Round | 19/09/2010 | The Strongest | - | Real Potosí | 4:2 | ||||
| 11. Round | 26/09/2010 | Real Potosí | - | CD Guabirá | 4:0 | ||||
| 12. Round | 02/10/2010 | Real Potosí | - | La Paz FC | 2:3 | ||||
| 14. Round | 10/10/2010 | Club Aurora | - | Real Potosí | 0:2 | ||||
| 15. Round | 17/10/2010 | Real Potosí | - | Bolívar | 1:1 | ||||
| 16. Round | 24/10/2010 | Real Mamoré | - | Real Potosí | 2:1 |  |
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| 17. Round | 04/11/2010 | Real Potosí | - | Club San José | 1:3 | ||||
| 19. Round | 07/11/2010 | Real Potosí | - | Blooming | 3:0 | ||||
| 20. Round | 14/11/2010 | Jorge Wilstermann | - | Real Potosí | 1:1 | ||||
| 21. Round | 21/11/2010 | Real Potosí | - | The Strongest | 2:3 |
Argentina