| 1. Round | 30/07/2022 | Deportivo Maldonado | - | Nacional | 2:1 | ||||
| 2. Round | 07/08/2022 | Danubio | - | Deportivo Maldonado | 0:0 | ||||
| 3. Round | 11/08/2022 | Deportivo Maldonado | - | Cerrito | 2:1 |  |
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| 6. Round | 22/08/2022 | Deportivo Maldonado | - | Peñarol | 1:1 | ||||
| 5. Round | 28/08/2022 | Liverpool | - | Deportivo Maldonado | 1:1 | ||||
| 4. Round | 02/09/2022 | Deportivo Maldonado | - | Rentistas | 2:1 |  |
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| 7. Round | 09/09/2022 | Montevideo City Torque | - | Deportivo Maldonado | 3:3 | ||||
| 8. Round | 13/09/2022 | Deportivo Maldonado | - | Montevideo Wanderers | 1:0 |  |
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| 10. Round | 23/09/2022 | Deportivo Maldonado | - | Boston River | 2:1 | |
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| 11. Round | 02/10/2022 | River Plate | - | Deportivo Maldonado | 0:0 | ||||
| 12. Round | 07/10/2022 | Deportivo Maldonado | - | Cerro Largo | 0:1 | ||||
| 13. Round | 11/10/2022 | Fénix | - | Deportivo Maldonado | 0:1 | ||||
| 14. Round | 15/10/2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 | ||||
| 15. Round | 24/10/2022 | Albion | - | Deportivo Maldonado | 1:3 |
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