| 1. Round | 31/08/2016 | Boston River | - | Defensor Sporting | 1:1 |  |
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| 2. Round | 04/09/2016 | Defensor Sporting | - | Juventud de Las Piedras | 0:1 | ||||
| 3. Round | 11/09/2016 | Defensor Sporting | - | Sud América | 2:0 | ||||
| 4. Round | 18/09/2016 | River Plate | - | Defensor Sporting | 0:5 | ||||
| 5. Round | 24/09/2016 | Defensor Sporting | - | CA Cerro | 0:1 | |
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| 6. Round | 02/10/2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 |  |
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| 7. Round | 09/10/2016 | Fénix | - | Defensor Sporting | 3:1 | ||||
| 8. Round | 16/10/2016 | Defensor Sporting | - | Liverpool | 1:3 | ||||
| 9. Round | 23/10/2016 | Plaza Colonia | - | Defensor Sporting | 0:1 | ||||
| 10. Round | 29/10/2016 | Rampla Juniors | - | Defensor Sporting | 0:1 | |
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| 12. Round | 20/11/2016 | Defensor Sporting | - | Nacional | 3:2 | |
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| 13. Round | 26/11/2016 | Defensor Sporting | - | Danubio | 0:0 | ||||
| 14. Round | 04/12/2016 | Defensor Sporting | - | Racing | 2:1 | ||||
| 15. Round | 10/12/2016 | Peñarol | - | Defensor Sporting | 0:2 |
Uruguay