| 1. Round | 05/02/2017 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 2. Round | 11/02/2017 | Defensor Sporting | - | CA Cerro | 1:1 | ||||
| 3. Round | 19/02/2017 | Sud América | - | Defensor Sporting | 1:2 | ||||
| 4. Round | 24/02/2017 | Defensor Sporting | - | Juventud de Las Piedras | 2:1 |  |
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| 5. Round | 05/03/2017 | Danubio | - | Defensor Sporting | 0:2 | |
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| 6. Round | 12/03/2017 | Defensor Sporting | - | Plaza Colonia | 1:3 | |
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| 7. Round | 19/03/2017 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 8. Round | 25/03/2017 | Defensor Sporting | - | Peñarol | 2:2 | ||||
| 9. Round | 02/04/2017 | Racing | - | Defensor Sporting | 0:0 | |
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| 11. Round | 16/04/2017 | Liverpool | - | Defensor Sporting | 0:1 | |
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| 12. Round | 23/04/2017 | Defensor Sporting | - | Boston River | 1:0 | |
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| 13. Round | 30/04/2017 | Montevideo Wanderers | - | Defensor Sporting | 2:3 |  |
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| 15. Round | 13/05/2017 | Fénix | - | Defensor Sporting | 1:2 | |
Uruguay