| 1. Round | 12/02/2000 | San Lorenzo | - | Newell's Old Boys | 1:0 |  |
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| 3. Round | 26/02/2000 | San Lorenzo | - | Gimnasia de La Plata | 1:1 | ||||
| 4. Round | 04/03/2000 | Talleres de Córdoba | - | San Lorenzo | 1:2 | ||||
| 5. Round | 11/03/2000 | San Lorenzo | - | Racing Club | 1:0 |  |
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| 6. Round | 18/03/2000 | Chacarita Juniors | - | San Lorenzo | 0:0 |  |
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| 7. Round | 30/03/2000 | San Lorenzo | - | Ferro Carril Oeste | 4:0 | ||||
| 8. Round | 08/04/2000 | San Lorenzo | - | Boca Juniors | 0:1 | ||||
| 10. Round | 15/04/2000 | San Lorenzo | - | Rosario Central | 1:0 | |
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| 11. Round | 12/05/2000 | Colón de Santa Fe | - | San Lorenzo | 2:1 | |
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| 13. Round | 27/05/2000 | Belgrano de Córdoba | - | San Lorenzo | 1:2 | |
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| 15. Round | 17/06/2000 | Lanús | - | San Lorenzo | 0:1 | |
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| 16. Round | 22/06/2000 | San Lorenzo | - | Argentinos Juniors | 3:2 | |
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| 17. Round | 01/07/2000 | Vélez Sarsfield | - | San Lorenzo | 1:0 | ||||
| 18. Round | 08/07/2000 | San Lorenzo | - | Gimnasia de Jujuy | 3:1 | |
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| 19. Round | 14/07/2000 | River Plate | - | San Lorenzo | 2:2 |
Argentina