| 2. Round | 31/07/2021 | Deportivo Guadalajara [U16] | - | CF Monterrey [U16] | 2:0 | ||||
| 3. Round | 07/08/2021 | Club León [U16] | - | Deportivo Guadalajara [U16] | 1:7 |  |
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| 5. Round | 21/08/2021 | Deportivo Guadalajara [U16] | - | Club Necaxa [U16] | 1:2 | ||||
| 7. Round | 04/09/2021 | Mazatlán FC [U16] | - | Deportivo Guadalajara [U16] | 1:7 | ||||
| 8. Round | 11/09/2021 | Deportivo Guadalajara [U16] | - | UANL Tigres [U16] | 3:1 | ||||
| 10. Round | 25/09/2021 | Deportivo Guadalajara [U16] | - | Atlético San Luis [U16] | 1:1 | ||||
| 14. Round | 23/10/2021 | Deportivo Guadalajara [U16] | - | Mazatlán FC [U16] | 5:3 | ||||
| 15. Round | 30/10/2021 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 1:7 |  |
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| 16. Round | 06/11/2021 | Deportivo Guadalajara [U16] | - | Atlas Guadalajara [U16] | 3:0 | ||||
| 18. Round | 20/11/2021 | UANL Tigres [U16] | - | Deportivo Guadalajara [U16] | 2:2 |
Mexico