| 3. Round | 26/01/2025 | Santos Laguna | - | CF América | 1:4 | ||||
| 5. Round | 02/02/2025 | Santos Laguna | - | Puebla FC | 0:2 | ||||
| 6. Round | 08/02/2025 | Club Necaxa | - | Santos Laguna | 3:2 | ||||
| 7. Round | 15/02/2025 | Mazatlán FC | - | Santos Laguna | 1:1 | ||||
| 9. Round | 20/02/2025 | Santos Laguna | - | Cruz Azul | 0:1 | ||||
| 12. Round | 15/03/2025 | UANL Tigres | - | Santos Laguna | 3:0 | ||||
| 16. Round | 17/04/2025 | Pumas UNAM | - | Santos Laguna | 2:0 |
Mexico