| 1. Round | 05/07/2024 | Puebla FC [U23] | - | Santos Laguna [U23] | 3:2 |  |
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| 3. Round | 16/07/2024 | Atlas Guadalajara [U23] | - | Santos Laguna [U23] | 3:0 | ||||
| 4. Round | 20/07/2024 | Santos Laguna [U23] | - | UANL Tigres [U23] | 0:3 | ||||
| 5. Round | 24/08/2024 | Club León [U23] | - | Santos Laguna [U23] | 0:0 | |
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| 6. Round | 01/09/2024 | Santos Laguna [U23] | - | Club Necaxa [U23] | 2:2 | ||||
| 7. Round | 15/09/2024 | Santos Laguna [U23] | - | CF Monterrey [U23] | 0:0 | ||||
| 8. Round | 18/09/2024 | Club Tijuana [U23] | - | Santos Laguna [U23] | 1:0 | ||||
| 9. Round | 22/09/2024 | Santos Laguna [U23] | - | Deportivo Toluca [U23] | 2:1 | |
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| 10. Round | 28/09/2024 | Atlético San Luis [U23] | - | Santos Laguna [U23] | 3:1 | ||||
| 11. Round | 06/10/2024 | Santos Laguna [U23] | - | FC Juárez [U23] | 3:1 | ||||
| 13. Round | 22/10/2024 | Santos Laguna [U23] | - | CF Pachuca [U23] | 2:3 | ||||
| 15. Round | 02/11/2024 | Cruz Azul [U23] | - | Santos Laguna [U23] | 0:2 |
Mexico