| 1. Round | 04/02/2018 | Defensor Sporting | - | Atenas | 3:0 | ||||
| 2. Round | 11/02/2018 | Danubio | - | Defensor Sporting | 2:1 | ||||
| 3. Round | 18/02/2018 | Defensor Sporting | - | Torque | 2:1 | ||||
| 4. Round | 24/02/2018 | Rampla Juniors | - | Defensor Sporting | 1:1 |  |
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| 5. Round | 04/03/2018 | Defensor Sporting | - | Fénix | 3:2 | ||||
| 6. Round | 10/03/2018 | Nacional | - | Defensor Sporting | 2:0 | |
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| 7. Round | 17/03/2018 | Defensor Sporting | - | Progreso | 1:1 | ||||
| 8. Round | 24/03/2018 | Defensor Sporting | - | CA Cerro | 2:1 | ||||
| 9. Round | 28/03/2018 | Racing | - | Defensor Sporting | 2:2 | |
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| 10. Round | 01/04/2018 | Defensor Sporting | - | River Plate | 5:2 | ||||
| 11. Round | 08/04/2018 | Montevideo Wanderers | - | Defensor Sporting | 1:2 | |
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| 12. Round | 13/04/2018 | Defensor Sporting | - | Liverpool | 1:0 | ||||
| 14. Round | 30/04/2018 | Defensor Sporting | - | Boston River | 2:1 | ||||
| 15. Round | 05/05/2018 | Peñarol | - | Defensor Sporting | 4:1 |  |
Uruguay