| 2. Round | 05/08/2000 | Newell's Old Boys | - | San Lorenzo | 1:0 |  |
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| 3. Round | 19/08/2000 | San Lorenzo | - | Racing Club | 3:1 | ||||
| 4. Round | 26/08/2000 | Belgrano de Córdoba | - | San Lorenzo | 0:1 | ||||
| 7. Round | 16/09/2000 | San Lorenzo | - | Lanús | 4:2 | ||||
| 8. Round | 23/09/2000 | River Plate | - | San Lorenzo | 2:2 | |
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| 10. Round | 13/10/2000 | Colón de Santa Fe | - | San Lorenzo | 3:2 | ||||
| 12. Round | 28/10/2000 | Independiente | - | San Lorenzo | 1:2 |  |
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| 14. Round | 09/11/2000 | CA Los Andes | - | San Lorenzo | 0:1 | ||||
| 16. Round | 25/11/2000 | San Lorenzo | - | Chacarita Juniors | 4:0 | ||||
| 17. Round | 02/12/2000 | Boca Juniors | - | San Lorenzo | 1:0 | ||||
| 18. Round | 09/12/2000 | San Lorenzo | - | Argentinos Juniors | 2:1 |
Argentina