| 5. Round | 13/02/2016 | River Plate | - | General Caballero ZC | 0:0 | ||||
| 6. Round | 20/02/2016 | Club Nacional | - | River Plate | 0:0 | ||||
| 7. Round | 27/02/2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Round | 02/03/2016 | Deportivo Capiatá | - | River Plate | 1:1 | ||||
| 9. Round | 05/03/2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
| 10. Round | 11/03/2016 | General Díaz | - | River Plate | 3:0 | ||||
| 11. Round | 21/03/2016 | River Plate | - | Club Olimpia | 0:3 | ||||
| 12. Round | 31/03/2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 18. Round | 30/04/2016 | Guaraní | - | River Plate | 4:2 | ||||
| 19. Round | 06/05/2016 | River Plate | - | Deportivo Capiatá | 1:1 | ||||
| 20. Round | 08/05/2016 | Club Rubio Ñu | - | River Plate | 1:2 | ||||
| 21. Round | 14/05/2016 | River Plate | - | General Díaz | 1:1 | ||||
| 22. Round | 21/05/2016 | Club Olimpia | - | River Plate | 3:0 |
Paraguay