| 1. Round | 09/07/2016 | Libertad | - | River Plate | 1:1 | ||||
| 2. Round | 16/07/2016 | River Plate | - | General Díaz | 0:0 | ||||
| 3. Round | 20/07/2016 | Guaraní | - | River Plate | 2:0 | ||||
| 4. Round | 24/07/2016 | River Plate | - | Club Olimpia | 0:2 | ||||
| 5. Round | 01/08/2016 | Club Rubio Ñu | - | River Plate | 5:1 | ||||
| 6. Round | 07/08/2016 | River Plate | - | General Caballero ZC | 1:1 |  |
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| 7. Round | 12/08/2016 | Sportivo Luqueño | - | River Plate | 1:0 | ||||
| 8. Round | 19/08/2016 | Deportivo Capiatá | - | River Plate | 0:3 | ||||
| 9. Round | 29/08/2016 | River Plate | - | Cerro Porteño | 2:3 | ||||
| 10. Round | 10/09/2016 | Sol de América | - | River Plate | 2:6 | ||||
| 11. Round | 18/09/2016 | River Plate | - | Club Nacional | 2:3 | ||||
| 12. Round | 24/09/2016 | River Plate | - | Libertad | 2:0 | ||||
| 13. Round | 30/09/2016 | General Díaz | - | River Plate | 2:0 | ||||
| 14. Round | 17/10/2016 | River Plate | - | Guaraní | 0:2 | ||||
| 15. Round | 23/10/2016 | Club Olimpia | - | River Plate | 5:3 | ||||
| 17. Round | 05/11/2016 | General Caballero ZC | - | River Plate | 1:0 |
Paraguay