| 1. Round | 17/07/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
| 2. Round | 22/07/2022 | Guaraní | - | General Caballero DJLM | 2:1 | ||||
| 3. Round | 24/07/2022 | General Caballero DJLM | - | Libertad | 3:2 |  |
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| 4. Round | 29/07/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
| 5. Round | 06/08/2022 | General Caballero DJLM | - | Tacuary | 0:4 | ||||
| 6. Round | 15/08/2022 | Sportivo Ameliano | - | General Caballero DJLM | 2:0 | ||||
| 12. Round | 19/09/2022 | Club Nacional | - | General Caballero DJLM | 1:0 | |
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| 13. Round | 24/09/2022 | General Caballero DJLM | - | Guaraní | 3:0 | ||||
| 14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 |
Paraguay