| 1. Round | 28/01/2023 | Guaireña FC | - | Club Nacional | 1:3 | ||||
| 3. Round | 11/02/2023 | General Caballero DJLM | - | Club Nacional | 0:1 | ||||
| 4. Round | 18/02/2023 | Club Nacional | - | Libertad | 1:2 | ||||
| 5. Round | 24/02/2023 | Sportivo Ameliano | - | Club Nacional | 0:0 |  |
|||
| 6. Round | 03/03/2023 | Club Nacional | - | Guaraní | 0:2 | ||||
| 2. Round | 08/03/2023 | Club Nacional | - | Club Olimpia | 1:1 | |
|||
| 7. Round | 12/03/2023 | Resistencia SC | - | Club Nacional | 0:1 |  |
|||
| 8. Round | 18/03/2023 | Club Nacional | - | Sportivo Luqueño | 0:1 | ||||
| 10. Round | 31/03/2023 | Tacuary | - | Club Nacional | 0:0 | ||||
| 11. Round | 08/04/2023 | Club Nacional | - | Sportivo Trinidense | 0:1 | ||||
| 12. Round | 12/04/2023 | Club Nacional | - | Guaireña FC | 2:2 | ||||
| 13. Round | 16/04/2023 | Club Olimpia | - | Club Nacional | 0:1 | ||||
| 17. Round | 14/05/2023 | Guaraní | - | Club Nacional | 2:2 | ||||
| 21. Round | 04/06/2023 | Club Nacional | - | Tacuary | 2:0 | ||||
| 22. Round | 10/06/2023 | Sportivo Trinidense | - | Club Nacional | 2:1 |
Paraguay