| 3. Round | 25/04/2021 | Deportes Iquique | - | San Marcos | 1:2 | ||||
| 4. Round | 03/05/2021 | Barnechea | - | Deportes Iquique | 3:1 | ||||
| 6. Round | 18/05/2021 | Deportes Copiapó | - | Deportes Iquique | 0:2 | ||||
| 12. Round | 24/07/2021 | Deportes Iquique | - | Santiago Morning | 1:2 |  |
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| 13. Round | 01/08/2021 | Rangers | - | Deportes Iquique | 1:0 | ||||
| 14. Round | 07/08/2021 | Deportes Iquique | - | Deportes Temuco | 2:2 | |
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| 15. Round | 15/08/2021 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 16. Round | 24/08/2021 | Coquimbo Unido | - | Deportes Iquique | 3:1 | ||||
| 17. Round | 29/08/2021 | Deportes Iquique | - | Fernández Vial | 1:3 | |
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| 19. Round | 05/09/2021 | Deportes Iquique | - | Barnechea | 4:2 | ||||
| 21. Round | 23/09/2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 | ||||
| 22. Round | 27/09/2021 | CD Magallanes | - | Deportes Iquique | 2:2 | ||||
| 23. Round | 03/10/2021 | Deportes Iquique | - | Santa Cruz | 6:1 | ||||
| 24. Round | 08/10/2021 | Universidad de Concepción | - | Deportes Iquique | 3:1 |  |
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| 25. Round | 13/10/2021 | Deportes Iquique | - | Cobreloa | 1:0 |
Argentina
Chile