| 7. Round | 21/08/2022 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 8. Round | 27/08/2022 | Libertad | - | Guaraní | 2:2 | ||||
| 9. Round | 02/09/2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Round | 11/09/2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 11. Round | 15/09/2022 | Guaraní | - | Sportivo Ameliano | 2:1 | ||||
| 14. Round | 03/10/2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
| 16. Round | 13/10/2022 | Guaraní | - | Sol de América | 4:1 | ||||
| 17. Round | 17/10/2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 20. Round | 30/10/2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Round | 06/11/2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Round | 13/11/2022 | Sportivo Ameliano | - | Guaraní | 4:2 |
Paraguay