| 2. Round | 29/01/2016 | Club Rubio Ñu | - | Club Nacional | 2:1 | ||||
| 3. Round | 03/02/2016 | Deportivo Capiatá | - | Club Rubio Ñu | 2:2 |  |
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| 4. Round | 07/02/2016 | Club Rubio Ñu | - | General Díaz | 0:0 | |
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| 5. Round | 12/02/2016 | Cerro Porteño | - | Club Rubio Ñu | 1:2 | ||||
| 6. Round | 19/02/2016 | Club Rubio Ñu | - | Sportivo Luqueño | 1:2 | |
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| 7. Round | 27/02/2016 | General Caballero ZC | - | Club Rubio Ñu | 0:1 | ||||
| 9. Round | 05/03/2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
| 10. Round | 13/03/2016 | Club Olimpia | - | Club Rubio Ñu | 4:1 | ||||
| 11. Round | 19/03/2016 | Club Rubio Ñu | - | Sol de América | 0:2 | ||||
| 1. Round | 26/03/2016 | Libertad | - | Club Rubio Ñu | 0:1 | ||||
| 13. Round | 07/04/2016 | Club Nacional | - | Club Rubio Ñu | 3:1 |  |
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| 20. Round | 08/05/2016 | Club Rubio Ñu | - | River Plate | 1:2 | ||||
| 16. Round | 12/05/2016 | Club Rubio Ñu | - | Cerro Porteño | 1:0 | ||||
| 21. Round | 15/05/2016 | Club Rubio Ñu | - | Club Olimpia | 1:4 | |
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| 22. Round | 20/05/2016 | Sol de América | - | Club Rubio Ñu | 1:2 | |
Paraguay