| 1. Round | 22/01/2020 | Blooming | - | Real Santa Cruz | 1:1 | ||||
| 2. Round | 26/01/2020 | Real Santa Cruz | - | The Strongest | 3:2 | ||||
| 4. Round | 02/02/2020 | Real Potosí | - | Real Santa Cruz | 2:1 | ||||
| 13. Round | 27/11/2020 | Real Santa Cruz | - | Club Aurora | 4:2 | ||||
| 14. Round | 30/11/2020 | Real Santa Cruz | - | Blooming | 0:2 | ||||
| 15. Round | 02/12/2020 | The Strongest | - | Real Santa Cruz | 4:2 | ||||
| 16. Round | 07/12/2020 | Club San José | - | Real Santa Cruz | 4:1 | ||||
| 17. Round | 09/12/2020 | Real Santa Cruz | - | Real Potosí | 3:1 | ||||
| 18. Round | 12/12/2020 | Real Santa Cruz | - | Always Ready | 0:3 | ||||
| 19. Round | 14/12/2020 | Real Santa Cruz | - | Jorge Wilstermann | 1:3 |
Bolivia