| 1. Round | 26/07/2015 | Santos Laguna | - | Club León | 1:3 | ||||
| 4. Round | 13/08/2015 | Club León | - | UANL Tigres | 2:1 | ||||
| 11. Round | 30/09/2015 | Club León | - | CF América | 3:0 | ||||
| 12. Round | 04/10/2015 | CF Monterrey | - | Club León | 4:0 | ||||
| 13. Round | 18/10/2015 | Club León | - | Pumas UNAM | 1:3 | ||||
| 14. Round | 25/10/2015 | Puebla FC | - | Club León | 1:0 | ||||
| 15. Round | 01/11/2015 | Club León | - | Atlas Guadalajara | 2:1 | ||||
| 16. Round | 08/11/2015 | CF Pachuca | - | Club León | 3:2 | ||||
| 17. Round | 22/11/2015 | Club León | - | Dorados de Sinaloa | 3:0 |
Ecuador