| 7. Round | 29/08/2021 | Isidro Metapán | - | Alianza | 1:2 | ||||
| 8. Round | 12/09/2021 | Alianza | - | Atlético Marte | 3:1 | ||||
| 9. Round | 16/09/2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
| 12. Round | 02/10/2021 | Municipal Limeño | - | Alianza | 0:3 |  |
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| 17. Round | 02/11/2021 | FAS | - | Alianza | 0:1 | ||||
| 19. Round | 13/11/2021 | Atlético Marte | - | Alianza | 2:1 | ||||
| 20. Round | 18/11/2021 | Alianza | - | Santa Tecla FC | 5:0 |
El Salvador