| 3. Round | 27/01/2022 | Alianza | - | AD Chalatenango | 3:1 | ||||
| 9. Round | 23/02/2022 | Once Municipal | - | Alianza | 1:2 |  |
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| 10. Round | 27/02/2022 | Alianza | - | Atlético Marte | 3:2 |  |
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| 11. Round | 06/03/2022 | Alianza | - | CD Águila | 0:0 | ||||
| 12. Round | 13/03/2022 | Isidro Metapán | - | Alianza | 0:0 | ||||
| 13. Round | 20/03/2022 | Alianza | - | Jocoro FC | 2:1 | ||||
| 15. Round | 03/04/2022 | FAS | - | Alianza | 1:3 | ||||
| 22. Round | 07/05/2022 | CD Águila | - | Alianza | 3:1 |
El Salvador