| 3. Round | 20/08/1977 | NAC Breda | - | FC Twente '65 | 2:0 | ||||
| 5. Round | 28/08/1977 | Roda JC Kerkrade | - | FC Twente '65 | 1:0 | ||||
| 7. Round | 11/09/1977 | Telstar | - | FC Twente '65 | 0:5 | ||||
| 11. Round | 16/10/1977 | SC NEC | - | FC Twente '65 | 0:2 | ||||
| 12. Round | 28/10/1977 | FC Twente '65 | - | FC Den Haag | 6:1 | ||||
| 13. Round | 05/11/1977 | Sparta Rotterdam | - | FC Twente '65 | 1:2 | ||||
| 23. Round | 07/03/1978 | Go Ahead Eagles | - | FC Twente '65 | 0:1 | ||||
| 27. Round | 11/03/1978 | FC VVV | - | FC Twente '65 | 1:1 | ||||
| 28. Round | 18/03/1978 | FC Twente '65 | - | SC NEC | 2:0 | ||||
| 29. Round | 25/03/1978 | FC Den Haag | - | FC Twente '65 | 0:0 | ||||
| 30. Round | 02/04/1978 | FC Twente '65 | - | Sparta Rotterdam | 1:0 | ||||
| 31. Round | 08/04/1978 | PSV Eindhoven | - | FC Twente '65 | 3:1 | ||||
| 34. Round | 30/04/1978 | AFC Ajax | - | FC Twente '65 | 4:1 |
Netherlands