| 2. Round | 02/05/2021 | Rio Grande Valley FC | - | New Mexico United | 1:0 | ||||
| 2. Round | 09/05/2021 | El Paso Locomotive | - | New Mexico United | 1:1 | ||||
| 2. Round | 16/05/2021 | New Mexico United | - | Austin Bold | 3:1 | ||||
| 2. Round | 22/05/2021 | Colorado Springs Switchbacks | - | New Mexico United | 1:3 |  |
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| 2. Round | 30/05/2021 | New Mexico United | - | Loudoun United | 0:1 | ||||
| 3. Round | 05/06/2021 | Real Monarchs SLC | - | New Mexico United | 0:1 | ||||
| 3. Round | 13/06/2021 | New Mexico United | - | Austin Bold | 0:0 | ||||
| 3. Round | 17/06/2021 | New Mexico United | - | San Antonio FC | 2:0 | ||||
| 3. Round | 26/06/2021 | Colorado Springs Switchbacks | - | New Mexico United | 3:1 | ||||
| 4. Round | 04/07/2021 | El Paso Locomotive | - | New Mexico United | 2:1 | ||||
| 5. Round | 15/08/2021 | New Mexico United | - | El Paso Locomotive | 1:1 | ||||
| 5. Round | 19/08/2021 | New Mexico United | - | Oakland Roots | 1:1 |
USA