| 6. Round | 22/02/2022 | Escorpiones | - | Sporting Canamy | 0:1 | ||||
| 7. Round | 26/02/2022 | Sporting Canamy | - | Cafetaleros de Chiapas | 1:1 |  |
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| 9. Round | 12/03/2022 | Sporting Canamy | - | Inter de Querétaro | 2:0 | ||||
| 10. Round | 20/03/2022 | Montañeses FC | - | Sporting Canamy | 1:0 | ||||
| 8. Round | 24/03/2022 | CD Zap | - | Sporting Canamy | 2:1 | ||||
| 11. Round | 28/03/2022 | Sporting Canamy | - | Leviatán FC | 3:1 | ||||
| 13. Round | 10/04/2022 | Yalmakan FC | - | Sporting Canamy | 2:0 |
Mexico