11. Round | 18/03/2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 0:1 | ||||
12. Round | 03/04/2022 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:0 | ||||
14. Round | 16/04/2022 | Santos Laguna [U20] | - | Gallos Blancos [U20] | 2:2 | ||||
15. Round | 19/04/2022 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 1:2 | ||||
17. Round | 01/05/2022 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 2:2 |