| 1. Round | 07/01/2023 | Santos Laguna [] | - | Atlético San Luis [] | 5:0 |  |
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| 2. Round | 14/01/2023 | Atlas Guadalajara [] | - | Santos Laguna [] | 1:3 | ||||
| 3. Round | 21/01/2023 | Santos Laguna [] | - | CF Monterrey [] | 3:1 |  |
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| 5. Round | 05/02/2023 | Santos Laguna [] | - | Club León [] | 3:0 | ||||
| 6. Round | 11/02/2023 | Deportivo Guadalajara [] | - | Santos Laguna [] | 0:0 | ||||
| 7. Round | 18/02/2023 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 8. Round | 25/02/2023 | Santos Laguna [] | - | Mazatlán FC [] | 2:0 | |
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| 9. Round | 04/03/2023 | UANL Tigres [] | - | Santos Laguna [] | 3:3 | ||||
| 10. Round | 11/03/2023 | Santos Laguna [] | - | Atlas Guadalajara [] | 3:0 | ||||
| 12. Round | 25/03/2023 | CF Monterrey [] | - | Santos Laguna [] | 2:1 | ||||
| 13. Round | 30/03/2023 | Santos Laguna [] | - | UANL Tigres [] | 4:2 | ||||
| 14. Round | 08/04/2023 | Mazatlán FC [] | - | Santos Laguna [] | 0:1 | |
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| 15. Round | 15/04/2023 | Santos Laguna [] | - | Deportivo Guadalajara [] | 5:3 | ||||
| 16. Round | 22/04/2023 | Atlético San Luis [] | - | Santos Laguna [] | 0:1 | ||||
| 17. Round | 29/04/2023 | Club León [] | - | Santos Laguna [] | 3:0 | ||||
| 18. Round | 06/05/2023 | Santos Laguna [] | - | Club Tijuana [] | 2:2 |
Mexico