| 2. Round | 08/04/2018 | Nashville SC | - | Charlotte Independence | 2:0 | ||||
| 2. Round | 15/04/2018 | Charlotte Independence | - | North Carolina FC | 0:2 | ||||
| 3. Round | 06/05/2018 | Charleston Battery | - | Charlotte Independence | 2:0 |  |
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| 4. Round | 14/06/2018 | Atlanta United II | - | Charlotte Independence | 1:1 | ||||
| 4. Round | 30/06/2018 | Bethlehem Steel FC | - | Charlotte Independence | 4:1 |  |
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| 5. Round | 12/07/2018 | Charlotte Independence | - | Nashville SC | 1:0 | ||||
| 5. Round | 19/07/2018 | FC Cincinnati | - | Charlotte Independence | 2:0 | ||||
| 5. Round | 22/07/2018 | Louisville City FC | - | Charlotte Independence | 4:1 | ||||
| 6. Round | 19/08/2018 | Pittsburgh Riverhounds | - | Charlotte Independence | 0:0 | ||||
| 7. Round | 02/09/2018 | Charlotte Independence | - | Nashville SC | 1:0 | ||||
| 7. Round | 09/09/2018 | Charlotte Independence | - | Richmond Kickers | 2:1 | ||||
| 7. Round | 20/09/2018 | Charleston Battery | - | Charlotte Independence | 1:1 | ||||
| 7. Round | 23/09/2018 | Charlotte Independence | - | New York RB II | 1:1 | ||||
| 8. Round | 14/10/2018 | Charlotte Independence | - | North Carolina FC | 1:3 |
Uganda