| 1. Round | 14/01/2021 | Correcaminos UAT | - | Cancún FC | 3:0 | ||||
| 2. Round | 20/01/2021 | Cancún FC | - | Cimarrones de Sonora | 0:0 | ||||
| 3. Round | 28/01/2021 | Cancún FC | - | Atlético Morelia | 1:2 |  |
|||
| 4. Round | 04/02/2021 | TM Fútbol Club | - | Cancún FC | 1:1 | |
|||
| 5. Round | 10/02/2021 | Cancún FC | - | Dorados de Sinaloa | 1:0 | ||||
| 6. Round | 17/02/2021 | Club Celaya | - | Cancún FC | 4:0 | |
|||
| 7. Round | 25/02/2021 | Cancún FC | - | Tapatío | 1:0 | |
|||
| 8. Round | 03/03/2021 | Mineros de Zacatecas | - | Cancún FC | 2:0 | ||||
| 15. Round | 15/04/2021 | Pumas Tabasco | - | Cancún FC | 1:2 | |
Mexico