| 2. Round | 05/08/2000 | River Plate | - | Vélez Sarsfield | 2:1 | ||||
| 3. Round | 18/08/2000 | Colón de Santa Fe | - | River Plate | 1:2 | ||||
| 6. Round | 09/09/2000 | River Plate | - | Talleres de Córdoba | 4:1 | ||||
| 7. Round | 16/09/2000 | CA Los Andes | - | River Plate | 0:4 | ||||
| 10. Round | 14/10/2000 | River Plate | - | Boca Juniors | 1:1 | ||||
| 13. Round | 04/11/2000 | Gimnasia de La Plata | - | River Plate | 2:2 |  |
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| 14. Round | 10/11/2000 | River Plate | - | Newell's Old Boys | 2:0 | ||||
| 17. Round | 02/12/2000 | Almagro | - | River Plate | 4:5 | ||||
| 18. Round | 09/12/2000 | River Plate | - | Huracán | 1:1 | ||||
| 19. Round | 16/12/2000 | Lanús | - | River Plate | 3:2 |  |
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Argentina