| 1. Round | 22/08/2010 | Liverpool | - | Rampla Juniors | 3:1 |  |
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| 2. Round | 29/08/2010 | Defensor Sporting | - | Liverpool | 3:0 | ||||
| 3. Round | 05/09/2010 | Liverpool | - | Racing | 1:0 |  |
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| 5. Round | 26/09/2010 | Liverpool | - | Danubio | 1:1 | ||||
| 6. Round | 03/10/2010 | Nacional | - | Liverpool | 0:0 | ||||
| 7. Round | 09/10/2010 | Liverpool | - | Central Español | 2:2 | ||||
| 8. Round | 17/10/2010 | Liverpool | - | Bella Vista | 1:1 | |
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| 9. Round | 24/10/2010 | River Plate | - | Liverpool | 1:2 | ||||
| 10. Round | 31/10/2010 | Peñarol | - | Liverpool | 1:2 | ||||
| 11. Round | 07/11/2010 | El Tanque Sisley | - | Liverpool | 1:1 | |
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| 14. Round | 28/11/2010 | Liverpool | - | Montevideo Wanderers | 0:2 | ||||
| 15. Round | 04/12/2010 | CA Cerro | - | Liverpool | 2:1 |
Uruguay