| 1. Round | 18/01/2021 | Plaza Colonia | - | Liverpool | 0:0 | ||||
| 2. Round | 21/01/2021 | Deportivo Maldonado | - | Liverpool | 2:4 |  |
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| 3. Round | 30/01/2021 | Progreso | - | Liverpool | 0:4 | ||||
| 4. Round | 03/02/2021 | Liverpool | - | Rentistas | 2:2 | ||||
| 5. Round | 06/02/2021 | Fénix | - | Liverpool | 0:2 |  |
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| 6. Round | 10/02/2021 | Liverpool | - | Cerro Largo | 3:2 | ||||
| 7. Round | 14/02/2021 | CA Cerro | - | Liverpool | 1:1 | ||||
| 8. Round | 17/02/2021 | Liverpool | - | Montevideo Wanderers | 2:1 | |
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| 9. Round | 20/02/2021 | Defensor Sporting | - | Liverpool | 0:3 | |
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| 10. Round | 26/02/2021 | Liverpool | - | Peñarol | 1:1 | ||||
| 11. Round | 07/03/2021 | Danubio | - | Liverpool | 0:1 | |
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| 13. Round | 22/03/2021 | Nacional | - | Liverpool | 0:4 | |
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| 14. Round | 24/03/2021 | Liverpool | - | Montevideo City Torque | 4:1 | ||||
| 15. Round | 29/03/2021 | Boston River | - | Liverpool | 1:0 |
Uruguay