| 1. Round | 16/05/2021 | Deportivo Maldonado | - | Liverpool | 2:4 |  |
|||
| 2. Round | 24/05/2021 | River Plate | - | Liverpool | 3:2 | |
|||
| 3. Round | 29/05/2021 | Liverpool | - | Cerro Largo | 3:0 | ||||
| 4. Round | 04/06/2021 | Progreso | - | Liverpool | 1:3 | ||||
| 5. Round | 11/06/2021 | Liverpool | - | Sud América | 5:0 | ||||
| 6. Round | 17/06/2021 | Plaza Colonia | - | Liverpool | 2:1 | ||||
| 7. Round | 22/06/2021 | Liverpool | - | Fénix | 5:2 | ||||
| 8. Round | 27/06/2021 | Boston River | - | Liverpool | 1:1 | ||||
| 9. Round | 06/07/2021 | Liverpool | - | Montevideo Wanderers | 2:1 |  |
|||
| 10. Round | 12/07/2021 | Rentistas | - | Liverpool | 2:1 | ||||
| 11. Round | 25/07/2021 | Liverpool | - | Peñarol | 3:3 | ||||
| 12. Round | 01/08/2021 | Montevideo City Torque | - | Liverpool | 0:3 | |
|||
| 13. Round | 08/08/2021 | Liverpool | - | Villa Española | 2:2 | ||||
| 14. Round | 15/08/2021 | Nacional | - | Liverpool | 1:0 | |
|||
| 15. Round | 21/08/2021 | Liverpool | - | Cerrito | 3:0 | |
|
Uruguay