| 2. Round | 13/03/2021 | CD Guabirá | - | Bolívar | 3:1 | ||||
| 1. Round | 21/03/2021 | Bolívar | - | Real Potosí | 1:0 | ||||
| 3. Round | 03/04/2021 | Bolívar | - | Blooming | 2:0 |  |
|||
| 4. Round | 12/04/2021 | Bolívar | - | Independiente Petrolero | 1:0 | ||||
| 5. Round | 27/04/2021 | Club Aurora | - | Bolívar | 1:1 | |
|||
| 6. Round | 02/05/2021 | Bolívar | - | Real Tomayapo | 2:0 | ||||
| 8. Round | 12/07/2021 | Bolívar | - | Real Santa Cruz | 1:1 | ||||
| 12. Round | 01/08/2021 | Bolívar | - | Jorge Wilstermann | 4:0 | |
|||
| 13. Round | 03/08/2021 | Atlético Palmaflor | - | Bolívar | 2:2 | ||||
| 16. Round | 19/08/2021 | Real Potosí | - | Bolívar | 0:2 | ||||
| 17. Round | 22/08/2021 | Bolívar | - | CD Guabirá | 6:0 | ||||
| 23. Round | 25/10/2021 | Real Santa Cruz | - | Bolívar | 0:3 | ||||
| 24. Round | 28/10/2021 | Bolívar | - | Nacional Potosí | 4:2 | ||||
| 25. Round | 31/10/2021 | Oriente Petrolero | - | Bolívar | 1:3 | ||||
| 26. Round | 21/11/2021 | Bolívar | - | The Strongest | 0:1 | ||||
| 27. Round | 28/11/2021 | Jorge Wilstermann | - | Bolívar | 1:0 |
Bolivia