| 1. Round | 06/02/2022 | Royal Pari | - | Jorge Wilstermann | 0:2 | ||||
| 2. Round | 12/02/2022 | Always Ready | - | Royal Pari | 2:2 | ||||
| 3. Round | 19/02/2022 | Royal Pari | - | Blooming | 1:1 | ||||
| 4. Round | 26/02/2022 | Real Tomayapo | - | Royal Pari | 1:0 | ||||
| 6. Round | 21/03/2022 | CD Guabirá | - | Royal Pari | 0:3 |  |
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| 7. Round | 03/04/2022 | Bolívar | - | Royal Pari | 6:0 | ||||
| 8. Round | 09/04/2022 | Royal Pari | - | Independiente Petrolero | 5:1 | ||||
| 9. Round | 17/04/2022 | Jorge Wilstermann | - | Royal Pari | 2:2 | ||||
| 10. Round | 20/04/2022 | Royal Pari | - | Always Ready | 5:1 | ||||
| 16. Round | 21/05/2022 | Independiente Petrolero | - | Royal Pari | 0:0 |
Bolivia